Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant KRas NSCLC Models
BackgroundThe capacity of cancer cells to undergo epithelial mesenchymal here trans-differentiation has been implicated as a factor driving metastasis, through the acquisition of enhanced migratory/invasive cell programs and the engagement of anti-apoptotic mechanisms promoting drug and radiation resistance.Our aim was to define molecular signaling